Registration Dossier

Administrative data

Description of key information

Skin Irritation: According to REACH Annex VI column II this study does not have to be conducted  when the test substance is classified as very toxic in contact with skin. 107-07-3 is classified as "very toxic by inhalation, in contact with skin and if swallowed. "
However a study from literature is avaialable which concludes; 2-chloroethanol caused only barely perceptible reaction on normal and abraded skin under the conditions of this test. In this regard, only the pure material caused even a transient reaction to intact skin. The maximun average score is 0.6 for the undiluted compound after 24 hours. This was fully reversible within 72 hours. No further effects observed.
Eye irritation: Individual scores are not given however the avarage scores for all animals give sufficient information for C&L.. The average score for all animals for eye irritation for 24-48-72 hour is 0.27 for cornea, 1.9 for Iris, 1.9 for redness and 1.5 for chemosis. The effect are fully reversible in 7 days. The substance is therefore classified as mildly irritating to the eyes.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

Effects on eye irritation: slightly irritating

Effect level: empty Endpoint conclusion: Adverse effect observed

Justification for classification or non-classification

Based on the avialable data 2 -chloroethanol is not classified irritation to skin or eyes.