Registration Dossier
Registration Dossier
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EC number: 203-459-7 | CAS number: 107-07-3
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- repeated dose toxicity: oral
- Type of information:
- other: Secondary reference IUCLID4
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
Data source
Reference
- Title:
- No information
- Author:
- Ambrose A.M.
- Year:
- 1 950
- Bibliographic source:
- Arch. Ind. Hyg. Occup. Med., 2. 591-598
Materials and methods
- Principles of method if other than guideline:
- Method: other
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-chloroethanol
- EC Number:
- 203-459-7
- EC Name:
- 2-chloroethanol
- Cas Number:
- 107-07-3
- Molecular formula:
- C2H5ClO
- IUPAC Name:
- 2-chloroethan-1-ol
- Details on test material:
- IUCLID4 Test substance: as prescribed by 1.1 - 1.4
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: feed
- Duration of treatment / exposure:
- 220 Tage (0.24; 0.16; 0.08; 0.04; 0.02; 0.01 % im Futter); 403 Tage (0.12% im Futter); 7-49 Tage (0.32; 0.64; 1.28 %)
- Frequency of treatment:
- kontinuierlich
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.01; 0.02; 0.04; 0.08; 0.12; 0.16; 0.24; 0.32; 0.64; 1.28 % im Futter (ca. 45, 65, 90, 130, 180, 355, 700 mg/kg/d)
Basis:
- Control animals:
- yes, concurrent no treatment
- Details on study design:
- Post-exposure period: keine Angaben
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
RS-Freetext:
Pro Versuchsgruppe wurden je 5 Tiere eingesetzt.
Die Tiere der 3 hoechsten Dosisgruppen starben zwischen
dem 7. und 49. Versuchstag. In den niederen Dosisgruppen
wurde dosisabhaengig eine Wachstumshemmung und eine
signifikant reduzierte Koerpergewichtsentwicklung
festgestellt. Die Autoren beschrieben Ethylenchlorhydrin
im Futter ab einer Konzentration von 0.12 % als toxisch
bzw. es hatte ab dieser Dosierung einen hemmenden Effekt
auf das Wachstum. Bei der Sektion der Tiere wurden keine
pathologischen Veraenderungen festgestellt.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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