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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Repeated dose toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
repeated dose toxicity: dermal
Type of information:
other: Secondary reference IUCLID4
Adequacy of study:
other information
Reliability:
4 (not assignable)

Data source

Reference
Title:
No information
Author:
NTP
Year:
1985
Bibliographic source:
: "Toxicology and Carcinogenesis Studies of|2-Chloroethanol in F344/N Rats and Swiss CD-1 Mice", NIH|Publication No.86-2531, NTP TR 275

Materials and methods

Principles of method if other than guideline:
Method: other
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2-chloroethanol
EC Number:
203-459-7
EC Name:
2-chloroethanol
Cas Number:
107-07-3
Molecular formula:
C2H5ClO
IUPAC Name:
2-chloroethan-1-ol
Details on test material:
IUCLID4 Test substance: as prescribed by 1.1 - 1.4

Test animals

Species:
rat
Strain:
Fischer 344
Sex:
male/female

Administration / exposure

Details on exposure:
Route of Administration: dermal
Duration of treatment / exposure:
14 Tage
Frequency of treatment:
taeglich
Doses / concentrations
Remarks:
Doses / Concentrations:
114/147, 172/222, 226/313, 339/451, 442/611 mg/kg (maennl./weibl.; 20, 30, 40, 60, 80 mg/Tier)
Basis:

Control animals:
yes, concurrent vehicle
Details on study design:
Post-exposure period: keine

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

RS-Freetext:
Ein maennliches Tier der hoechsten Dosisgruppe und zwei
weibliche Tiere der 60 mg Gruppe starben waehrend der
Studie. Die Koerpergewichtsentwicklung war im Vergleich zur
Kontrolle unveraendert.

Applicant's summary and conclusion