Registration Dossier
Registration Dossier
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EC number: 203-459-7 | CAS number: 107-07-3
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- repeated dose toxicity: dermal
- Type of information:
- other: Secondary reference IUCLID4
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
Data source
Reference
- Title:
- No information
- Author:
- NTP
- Year:
- 1 985
- Bibliographic source:
- : "Toxicology and Carcinogenesis Studies of|2-Chloroethanol in F344/N Rats and Swiss CD-1 Mice", NIH|Publication No.86-2531, NTP TR 275
Materials and methods
- Principles of method if other than guideline:
- Method: other
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-chloroethanol
- EC Number:
- 203-459-7
- EC Name:
- 2-chloroethanol
- Cas Number:
- 107-07-3
- Molecular formula:
- C2H5ClO
- IUPAC Name:
- 2-chloroethan-1-ol
- Details on test material:
- IUCLID4 Test substance: as prescribed by 1.1 - 1.4
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
Administration / exposure
- Details on exposure:
- Route of Administration: dermal
- Duration of treatment / exposure:
- 14 Tage
- Frequency of treatment:
- taeglich
Doses / concentrations
- Remarks:
- Doses / Concentrations:
114/147, 172/222, 226/313, 339/451, 442/611 mg/kg (maennl./weibl.; 20, 30, 40, 60, 80 mg/Tier)
Basis:
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- Post-exposure period: keine
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
RS-Freetext:
Ein maennliches Tier der hoechsten Dosisgruppe und zwei
weibliche Tiere der 60 mg Gruppe starben waehrend der
Studie. Die Koerpergewichtsentwicklung war im Vergleich zur
Kontrolle unveraendert.
Applicant's summary and conclusion
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