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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
November 1988- July 1989
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Only an LD50 value is reported. No further details.

Data source

Reference
Reference Type:
publication
Title:
The international validation of a fixed-dose procedure as an alternative to the classical LD50 test.
Author:
Van den Heuvel, M.J., Clark, D.G., Fielder, R.J., Koundakjian, P.P., Oliver, G.J.A., Pelling, D. Tomlinson, N.J., Walker, A.P.
Year:
1990
Bibliographic source:
Fd Chem. Toxic. Vol. 28, No. 7, pp. 469-482

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
GLP compliance:
not specified
Test type:
other: standard acute method and draft fixed dose method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-chloroethanol
EC Number:
203-459-7
EC Name:
2-chloroethanol
Cas Number:
107-07-3
Molecular formula:
C2H5ClO
IUPAC Name:
2-chloroethan-1-ol
Details on test material:
2-chloroethyl alcohol

Test animals

Species:
rat

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
60 mg/kg bw
95% CL:
50 - 73
Remarks on result:
other: classical LD50

Applicant's summary and conclusion

Executive summary:

In an international study involving 33 laboratories in 11 countries, the acute oral toxicity to the rat of 20 substances and preparations was evaluated using a fixed-dose procedure and the results compared with those obtained for the test materials using the classical LD50 test. The LD50 for 2 -chloroethanol found in the standard study is 60 mg/kg bw/day.