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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Morpholine
Author:
ILO (International Labour Office)
Year:
1972
Bibliographic source:
In: Encyclopaedia of occupational health and safety. 2nd ed. Vol. II (L-Z). Geneva, Switzerland: International Labour Office, 915-916

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Deviations:
not specified
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Morpholine
EC Number:
203-815-1
EC Name:
Morpholine
Cas Number:
110-91-8
Molecular formula:
C4H9NO
IUPAC Name:
morpholine
Test material form:
liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
not specified
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
4 h
Concentrations:
6734 ppm ≈ 23,569 mg/m³
No. of animals per sex per dose:
6 animals
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Statistics:
No data

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LC0
Effect level:
24 mg/L air
Exp. duration:
4 h
Mortality:
No deaths (0/6) were noted.
Clinical signs:
other: There were signs of irritation and stained hair
Body weight:
The body weight gain during the observation period was normal.
Gross pathology:
No gross lesions were noted at necropsy.
Other findings:
In a further study also reported in this publication 6 rats have been exposed to 8497 ppm (31 mg/L) of morpholine vapour in a 8-h exposure and one animal died. The survivors gained weight normally and had no visible lesions at autopsy.

Applicant's summary and conclusion