Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-815-1 | CAS number: 110-91-8
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
With high probability acutely not harmful to fish.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 180 mg/L
Marine water fish
Marine water fish
- Effect concentration:
- 179 mg/L
Additional information
The assessment of the short-term toxicity to fish is based on the available data from studies with several freshwater and saltwater species:
The selected key studies (Calamari et al., 1980) for freshwater fish were performed according to IRSA (1980) with Oncorhynchus mykiss in soft and in hard water. The test concentrations were analytically verified. The resulting 96-h LC50 values were 180 mg/L (nominal) for soft water and 380 mg/L (nominal) for hard water, respectively.
The key data are supported by the results of several freshwater and marine studies as summarized in the following table:
Reference | Guideline | Test Species | Duration / Dose Descriptor | Effect Concentration [mg/L] | Remarks |
NITE (1997) | OECD 203 | Oryzias latipes | 96-h LC50 | > 100 | nominal; analytically verified; limit test |
OECD 204 | 14-d LC50 | > 92 | measured | ||
Dawson et al. (1977) | No guideline specified* | Lepomis macrochirus | 96-h LC50 | 350 | nominal |
Menidia beryllina (marine species) | 96-h LC50 | 400 | nominal | ||
Wellens H. (1982) | UBA, Document I 5.3-97125-2/6 | Danio rerio | 96-h LC50 | > 1000 | nominal |
McCain & Peck (1976) | APHA (1965)** | Vala mugil engeli (marine species) | 96-h LC50 | 179 | nominal; geometric mean of LC0 and LC100*** |
Gambusia affinis (marine species) | 96-h LC50 | 423 | nominal; geometric mean of LC0 and LC100*** | ||
Tilapia sp. (marine species) | 96-h LC0 | >1000 | nominal; only LC0 reported |
*Study meets generally accepted scientific principles, acceptable for assessment.
**American Public Health Association (1965). Standard Methods for the Examination of Water and Wastewater, 12th ed. New York, USA.
*** The calculation of the LC50 is not done in a proper way since the geometric mean between LC0 and LC100 was used. This is only correct if there is no effective concentration between LC0 and LC100. In this case, there is a concentration in between.
The stability of morpholine (CAS 110-91-8) in the test medium has not been analytically confirmed in all supporting studies, but is considered to be stable due to the high water solubility (completely miscible), the moderate vapour pressure (VP = 9.8 hPa, at 20 °C) and the low Henry´s law constant (HLC, uncharged: 0.0115 Pa*m3/mol, at 25 °C) of the substance.
Conclusion:
Summing up the available freshwater and saltwater data, morpholine is assessed to be with high probability not acutely harmful to fish.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Route: .live1