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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

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Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Description of key information

With high probability acutely not harmful to fish.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Dose descriptor:
Effect concentration:
> 100 mg/L

Additional information

The assessment of the short-term toxicity to fish is based on the available and valid data from two studies with Oryzias latipes as test species by NITE (1997). In an acute toxicity study according to OECD 203 and performed under GLP, the effect on fish due to the exposure to morpholine was observed in a semi-static limit test (water exchange after 48 h). No mortality was observed during the exposure period of 96 hours at the test concentration of 100 mg/L. The test concentrations were analytically verified. This study was selected as key study.

The result is supported by a prolonged toxicity study which was also performed under GLP by NITE (1997). The test species was O. latipes. The test was performed under flow-through conditions. The test concentrations were analytically verified. The LC50 was determined to be > 100 mg/L (nominal; > 92 mg/L, mean-measured).


It can be concluded that morpholine is with high probabaility acutely not harmful to fish.