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EC number: 203-815-1 | CAS number: 110-91-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
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- Nanomaterial agglomeration / aggregation
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- Nanomaterial pour density
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- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
With high probability acutely not harmful to fish.
Key value for chemical safety assessment
- LC50 for freshwater fish:
- 180 mg/L
- LC50 for marine water fish:
- 179 mg/L
Additional information
The assessment of the short-term toxicity to fish is based on the available data from studies with several freshwater and saltwater species:
The selected key studies (Calamari et al., 1980) for freshwater fish were performed according to IRSA (1980) with Oncorhynchus mykiss in soft and in hard water. The test concentrations were analytically verified. The resulting 96-h LC50 values were 180 mg/L (nominal) for soft water and 380 mg/L (nominal) for hard water, respectively.
The key data are supported by the results of several freshwater and marine studies as summarized in the following table:
Reference | Guideline | Test Species | Duration / Dose Descriptor | Effect Concentration [mg/L] | Remarks |
NITE (1997) | OECD 203 | Oryzias latipes | 96-h LC50 | > 100 | nominal; analytically verified; limit test |
OECD 204 | 14-d LC50 | > 92 | measured | ||
Dawson et al. (1977) | No guideline specified* | Lepomis macrochirus | 96-h LC50 | 350 | nominal |
Menidia beryllina (marine species) | 96-h LC50 | 400 | nominal | ||
Wellens H. (1982) | UBA, Document I 5.3-97125-2/6 | Danio rerio | 96-h LC50 | > 1000 | nominal |
McCain & Peck (1976) | APHA (1965)** | Vala mugil engeli (marine species) | 96-h LC50 | 179 | nominal; geometric mean of LC0 and LC100*** |
Gambusia affinis (marine species) | 96-h LC50 | 423 | nominal; geometric mean of LC0 and LC100*** | ||
Tilapia sp. (marine species) | 96-h LC0 | >1000 | nominal; only LC0 reported |
*Study meets generally accepted scientific principles, acceptable for assessment.
**American Public Health Association (1965). Standard Methods for the Examination of Water and Wastewater, 12th ed. New York, USA.
*** The calculation of the LC50 is not done in a proper way since the geometric mean between LC0 and LC100 was used. This is only correct if there is no effective concentration between LC0 and LC100. In this case, there is a concentration in between.
The stability of morpholine (CAS 110-91-8) in the test medium has not been analytically confirmed in all supporting studies, but is considered to be stable due to the high water solubility (completely miscible), the moderate vapour pressure (VP = 9.8 hPa, at 20 °C) and the low Henry´s law constant (HLC, uncharged: 0.0115 Pa*m3/mol, at 25 °C) of the substance.
Conclusion:
Summing up the available freshwater and saltwater data, morpholine is assessed to be with high probability not acutely harmful to fish.
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