Registration Dossier
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EC number: 203-815-1 | CAS number: 110-91-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1967-02-06
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented report which meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 967
- Report Date:
- 1967
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- Principles of method if other than guideline:
- BASF-Test, see details in the section "Any other information on materials and methods incl. tables".
- GLP compliance:
- no
- Remarks:
- study was performed prior to GLP
- Test type:
- standard acute method
- Limit test:
- no
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- - Name of test material: Morpholine (1, 4-Tetrahydrooxazin)
- Physical state: liquid
- Analytical purity: 99.2 %
- Impurities: 0.2 to 0.3 % water, 0.1 % diethylene glycol, 0.4 % n-ethylmorpholine
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Age at study initiation: young adult (based on body weight)
- Weight at study initiation: 180 to 288 g (male), 156 - 226 g (female)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 4 and 20 % - Doses:
- 1600, 2000, 2500 and 3200 mL/kg bw = 1600, 2000, 2500 and 3200 mg/kg bw (conversion in mg/kg bw is based on the density d=1.00 g/cm³)
- No. of animals per sex per dose:
- 5 animals (at 1600, 2000 and 3200 mg/kg bw)
10 animals (at 2500 mg/kg bw) - Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: several times on the day of application and daily thereafter
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, macroscopical examination - Statistics:
- Not indicated.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 900 mg/kg bw
- Mortality:
- See details in the section "Any other information on results incl. tables".
- Clinical signs:
- At 3200 and 2500 mg/kg bw: squatting posture, ruffled fur, abdominal position, shallow and irregular respiration, closed eyes. After 24 hours the surviving animals showed red crusted eyes and noses, and trembling gait with delayed motion of the hind limbs.
2000 and 1600 mg/kg bw: accellerated respiration, squatting posture, red crusted noses, high stepping gait. - Body weight:
- No data
- Gross pathology:
- Animals that died: 4x diarrhoea, 1x haemorrhagic enteritis.
Sacrificed animals: no abnormalities.
Any other information on results incl. tables
Mortality:
Dose (mg/kg bw) | Gender | 1 h | 24 h | 48 h | 7 days | 14 days | ||||
3200 | male | 0/5 | 5/5 | 5/5 | 5/5 | - | ||||
3200 | female | 0/5 | 5/5 | 5/5 | 5/5 | - | ||||
2500 | male | 0/10 | 4/10 | 4/10 | 4/10 | 4/10 | ||||
2500 | female | 0/10 | 10/10 | 10/10 | 10/10 | 10/10 | ||||
2000 | male | 0/5 | 0/5 | 1/5 | 1/5 | - | ||||
2000 | female | 0/5 | 5/5 | 5/5 | 5/5 | - | ||||
1600 | male | 0/5 | 1/5 | 1/5 | 1/5 | - | ||||
1600 | female | 0/5 | 1/5 | 1/5 | 1/5 | - |
The test substance caused dose dependent toxicity after a single ingestion and local irritations to exposed tissues.
Applicant's summary and conclusion
- Executive summary:
In an acute oral toxicity study according to an internal BASF method (BASF AG, 1967), Sprague Dawley rats were given a single oral dose of Morpholine (99.2 %) diluted in water at 1600, 2000, 2500 or 3200 mg/kg bw. Animals were then observed for mortality and for clinical symptoms of toxicity for 14 days. All animals were subjected to necropsy. The oral LD50 was estimated as 1900 mg/kg bw. This acute oral study is classified as acceptable. It satisfies the guideline requirement for an acute oral study according to OECD 401 in principle.
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