Registration Dossier
Registration Dossier
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EC number: 203-815-1 | CAS number: 110-91-8
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Based on the GHS, no chronic toxicity is anticipated at an NOEC or EC10 > 1 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 8.134 mg/L
Additional information
The long-term toxicity to aquatic invertebrates was assessed in an OECD 211 study using Daphnia magna as test organism (NITE, 1997). Based on the reproduction the following effect values were determined: 21-d NOEC = 5 mg/L; 21-d EC50 = 12 mg/L (based nominal concentrations, verified by analytical measurement). The originally reported data were re-evaluated with ToxRat Professional v3.2.1 (BASF SE, 2017) resulting in a 21-d EC10 of 8.134 mg/L (21-d EC50 = 12.191 mg/L).
Remark on assessment:
The assessment of the long-term toxicity to aquatic invertebrates is based on the 21-d EC10 of 8.134 mg/L (recalculated with ToxRat v3.2.1) and not on the 21-d NOEC of 5.0 mg/L originally reported in the study. According to the Guidance on information requirements and chemical safety assessment Chapter R.10: Characterisation of dose [concentration]-response for environment ", an EC10 for a long-term test which is obtained using an appropriate statistical method (usually regression analysis) will be used preferentially. [...] There has been a recommendation within OECD in 1996 to phase out the use of the NOEC, in particular as it can correspond to large and potentially biologically important magnitudes of effect. The advantage of regression method for the estimation of ECx is that information from the whole concentration-effect relationship is taken into account and that confidence intervals can be calculated. These methods result in an ECx, where x is a low effect percentile (e.g. 5-20%). It makes results from different experiments more comparable than NOECs".
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