Registration Dossier
Registration Dossier
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EC number: 209-128-3 | CAS number: 556-52-5
Endpoint summary
Administrative data
Description of key information
Additional information
Hydrolysis:
In accordance with REACH Annex VIII column 2, the study does not need to be conducted if the substance is readily biodegradable or highly insoluble in water. However, we have supplied some data in respect of this point.
The half-life of the substance was found to be 102 h at 37 degrees celcius. (Lawley, P.D., & Searle, C.E. 1973)
The half-life of the substance was 28 hours at pH 7 (Norppa, H. et al., 1981)
In a 2 % solution of glycidol treated at 37 degree C for 30
min with hydrochloric acid of different concentration,
glycerol was found as major product. Additionally,
epichlorohydrin was formed:
HCl (mol/l) % of glycidol reacted to epichlorohydrin
0.4 5.6
0.1 2.7
0.05 1.6
0.02 0.85 (Jones, A.R. & O' Brien, R.W. 1980)
Biodegradation:
In the key study, after 28 days, the mean of degradabilities by BOD measurement was 85%, the mean of degradabilities by DOC measurement was 96%, and all of the disappearance rates of the test substance were more than or equal to 98%, all leading to the judgment that the test substance is readily biodegradable (Mitsubishi Chemical Safety Institute, 2001).
A Pseudomonas sp. strain was isolated by enrichment culture from soil using 2,3-dichloro-propanol-1 as the sole carbon source.
> 99 % degradation occurred after 24 hours. Therefore the substance is considered readily biodegradable.(Castro, C.E. & Bartnicki, E.W., 1968)
In one strain, an inducible epoxide hydrase using glycidol as substrate was detected in 40000 g crude supernatants from bacterial extracts. Enzyme activity (30 degree C, pH 7.5, 5 mM glycidol): bacteria grown on epichlorohydrin 107 U/ g prot., grown on glycidol 817 U/g prot.Glycerol was identified as hydrolysis product (van den Wijngaard, A.J. et al., J., 1989).
2,3-epoxypropan-1-ol is considered to be readily biodegradable.
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