Registration Dossier
Registration Dossier
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EC number: 228-602-0 | CAS number: 6303-30-6
Endpoint summary
Administrative data
Description of key information
The pH determination of a 1 g diisobutyl phosphate /100 mL water solution was done with a pH meter equipped with a calibrated single rod glass electrode. A pH-value of 1.5 at 20°C was determined (see IUCLID section 4.20 pH).
In addition, the acidity of diisobutyl phosphate was determined in accordance to OECD Guideline 122. The acidity of diisobutyl phosphate calculated as H2SO4 is 23.3 %, equal to a pH of 1.3. This confirms the measurements by glass rod electrode (see IUCLID section 4.20 pH).
According to Guidance to Regulation (EC) No 1272/2008 on classification, labelling and packaging (CLP) of substances and mixtures, Version 5.0, July 2017, section 3.2.2.1.2.2. ‘pH and acid/alkaline reserve it is stated’: ‘’In the absence of any other information, a substance is considered as corrosive to skin (Skin Corrosion Category 1) if it has a pH ≤ 2 or a pH ≥ 11,5”.
The experimental determined pH-value of diisobutyl phosphate is below pH 2. Therefore, a classification of diisobutyl phosphate as corrosive to skin (Skin Corrosion Category 1) is justified.
According to COMMISSION REGULATION (EU) 2016/1688 of 20 September 2016 amending Annex VII to Regulation (EC) No 1907/2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), Annex VII, ‘8.3.Skin sensitisation ’ column 2: The study(ies) under point 8.3.1 [Skin sensitisation, in vitro/in chemico] and 8.3.2 [Skin sensitisation, in vivo] do not need to be conducted if: — the substance is classified as skin corrosion (Category 1), or — the substance is a strong acid (pH ≤ 2,0) or base (pH ≥ 11,5).
These criteria are fulfilled as the pH of diisobutyl phosphate is below pH 2. A skin sensitisatiion study is therefore not required according to CLP criteria and COMMISSION REGULATION (EU) 2016/863 of 31 May 2016 amending Annexes VII and VIII to Regulation (EC) No 1907/2006.
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
The experimental determined pH-value of diisobutyl phosphate is below pH 2. A classification according to CLP classification criteria (Regulation (EC) No 1272/2008) is not adequate.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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