Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 228-602-0 | CAS number: 6303-30-6
Endpoint summary
Administrative data
Description of key information
The pH determination of a 1 g diisobutyl phosphate /100 mL water solution was done with a pH meter equipped with a calibrated single rod glass electrode. A pH-value of 1.5 at 20°C was determined (see IUCLID section 4.20 pH).
In addition, the acidity of diisobutyl phosphate was determined in accordance to OECD Guideline 122. The acidity of diisobutyl phosphate calculated as H2SO4 is 23.3 %, equal to a pH of 1.3. This confirms the measurements by glass rod electrode (see IUCLID section 4.20 pH).
According to Guidance to Regulation (EC) No 1272/2008 on classification, labelling and packaging (CLP) of substances and mixtures, Version 5.0, July 2017, section 3.2.2.1.2.2. ‘pH and acid/alkaline reserve it is stated’: ‘’In the absence of any other information, a substance is considered as corrosive to skin (Skin Corrosion Category 1) if it has a pH ≤ 2 or a pH ≥ 11,5”.
The experimental determined pH-value of diisobutyl phosphate is below pH 2. Therefore, a classification of diisobutyl phosphate as corrosive to skin (Skin Corrosion Category 1) is justified.
According to COMMISSION REGULATION (EU) 2016/863 of 31 May 2016 amending Annexes VII and VIII to Regulation (EC) No 1907/2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), Annex VII, section 8.5. Acute toxicity column 2: The study/ies do(es) not generally need to be conducted if: — the substance is classified as skin corrosion.
This criterion is fulfilled as the pH of diisobutyl phosphate is below pH 2. An acute oral toxicity study is therefore not required according to CLP criteria and COMMISSION REGULATION (EU) 2016/863 of 31 May 2016 amending Annexes VII and VIII to Regulation (EC) No 1907/2006.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
The pH determination of a 1 g diisobutyl phosphate /100 mL water solution was done with a pH meter equipped with a calibrated single rod glass electrode. A pH-value of 1.5 at 20°C was determined (see IUCLID section 4.20 pH).
In addition, the acidity of diisobutyl phosphate was determined in accordance to OECD Guideline 122. The acidity of diisobutylphosphate calculated as H2SO4 is 23.3 %, equal to a pH of 1.3. this confirms the measurements by glass rod electrode (see IUCLID section 4.20 pH).
According to Guidance to Regulation (EC) No 1272/2008 on classification, labelling and packaging (CLP) of substances and mixtures, Version 5.0, July 2017, section 3.2.2.1.2.2. ‘pH and acid/alkaline reserve it is stated’: ‘’In the absence of any other information, a substance is considered as corrosive to skin (Skin Corrosion Category 1) if it has a pH ≤ 2 or a pH ≥ 11,5”.
The experimental determined pH-value of diisobutyl phosphate is below pH 2. Therefore, a classification of diisobutyl phosphate as corrosive to skin (Skin Corrosion Category 1) is justified.
According to REGULATION (EC) No 1907/2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), Annex VII, section 8.5. Acute toxicity column 2 the study/ies do(es) not generally need to be conducted if: — the substance is classified as corrosive to the skin.
This criterion is fulfilled as the pH of diisobutyl phosphate is below pH 2. An acute oral toxicity study is therefore not required according to CLP criteria and REACH Regulation (EC) 1907/2006.
A classification according to CLP classification criteria (Regulation (EC) No 1272/2008) is not adequate.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
