Registration Dossier
Registration Dossier
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EC number: 228-602-0 | CAS number: 6303-30-6
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2020
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Reason / purpose for cross-reference:
- reference to other study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- GLP compliance:
- yes (incl. QA statement)
- Other quality assurance:
- ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)
- Type of method:
- estimation method (solubility ratio)
- Partition coefficient type:
- octanol-water
- Key result
- Type:
- log Pow
- Partition coefficient:
- >= 2.6
- Temp.:
- 20 °C
- pH:
- 1.4
- Details on results:
- The calculation following the equation:
log(POW )=log(C_O/C_W ) (With: C_O = solubility in water at 20 °C; C_W = solubility in n-octanol at 20 °C)
gives an estimated log POW of 2.6. - Conclusions:
- The logPOW of diisobutyl phosphate was estimated by calculaton. As for the 1-octanol solubility no exact value could be determined since the test substance is expected to be miscible with n-octanol in any ratio, the result is given as: log POW ≥ 2.6.
- Executive summary:
The estimation of the log POW is performed by calculation with the determined water solubility and the determined 1-octanol solubility. The determined water solubility from study 2020/0002/07 according to is 22.3 g/L. Solubility tests in ratios 1+10, 1+1 and 10+1 (w/w) of the test item in 1-octanol were performed and the test item is expected to be soluble in n-octanol in any ratio. Hence the 1-octanol solubility was determined to be ≥ 8259 g/L.
The calculation with these values gives an estimated log POW of 2.6, following the equation:
log(POW )=log(CO/CW )
As for the 1-octanol solubility no exact value could be determined, the result is given as:
log POW ≥ 2.6.
Reference
Description of key information
The estimation of the log POW is performed by calculation with the determined water solubility and the determined 1-octanol solubility. The determined water solubility is 22.3 g/L.
The determined value for 1-octanol solubility is ≥ 8259 g/L. As for the 1-octanol solubility no exact value could be determined, the result is estimated as: log Pow ≥ 2.6 by calculation.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 2.6
- at the temperature of:
- 20 °C
Additional information
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