Registration Dossier
Registration Dossier
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EC number: 228-602-0 | CAS number: 6303-30-6
Endpoint summary
Administrative data
Description of key information
Skin irritation/corrosion:
The pH determination of a 1 g diisobutyl phosphate /100 mL water solution was done with a pH meter equipped with a calibrated single rod glass electrode. A pH-value of 1.5 at 20°C was determined (see IUCLID section 4.20 pH).
In addition, the acidity of diisobutyl phosphate was determined in accordance to OECD Guideline 122. The acidity of diisobutyl phosphate calculated as H2SO4 is 23.3 %, equal to a pH of 1.3. This confirms the measurements by glass rod electrode (see IUCLID section 4.20 pH).
According to Guidance to Regulation (EC) No 1272/2008 on classification, labelling and packaging (CLP) of substances and mixtures, Version 5.0, July 2017, section 3.2.2.1.2.2. ‘pH and acid/alkaline reserve it is stated’: ‘’In the absence of any other information, a substance is considered as corrosive to skin (Skin Corrosion Category 1) if it has a pH ≤ 2 or a pH ≥ 11,5”.
The experimental determined pH-value of diisobutyl phosphate is below pH 2. Therefore, a classification of diisobutyl phosphate as corrosive to skin (Skin Corrosion Category 1) is justified.
According to COMMISSION REGULATION (EU) 2016/863 of 31 May 2016 amending Annexes VII and VIII to Regulation (EC) No 1907/2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), Annex VII, ‘8.1. Skin corrosion/irritation’ column 2: The study/ies do(es) not need to be conducted if: —the substance is a strong acid (pH ≤ 2,0) or base (pH ≥ 11,5) and the available information indicates that it should be classified as skin corrosion (Category 1).
This criterion is fulfilled as the pH of diisobutyl phosphate is below pH 2. A skin irritation/corrosion toxicity study is therefore not required according to CLP criteria and COMMISSION REGULATION (EU) 2016/863 of 31 May 2016 amending Annexes VII and VIII to Regulation (EC) No 1907/2006.
Eye irritation:
The pH determination of a 1 g diisobutyl phosphate /100 mL water solution was done with a pH meter equipped with a calibrated single rod glass electrode. A pH-value of 1.5 at 20°C was determined (see IUCLID section 4.20 pH).
In addition, the acidity of diisobutyl phosphate was determined in accordance to OECD Guideline 122. The acidity of diisobutyl phosphate calculated as H2SO4 is 23.3 %, equal to a pH of 1.3. This confirms the measurements by glass rod electrode (see IUCLID section 4.20 pH).
According to Guidance to Regulation (EC) No 1272/2008 on classification, labelling and packaging (CLP) of substances and mixtures, Version 5.0, July 2017, section 3.2.2.1.2.2. ‘pH and acid/alkaline reserve it is stated’: ‘’In the absence of any other information, a substance is considered as corrosive to skin (Skin Corrosion Category 1) if it has a pH ≤ 2 or a pH ≥ 11,5”.
The experimental determined pH-value of diisobutyl phosphate is below pH 2. Therefore, a classification of diisobutyl phosphate as corrosive to skin (Skin Corrosion Category 1) is justified.
According to COMMISSION REGULATION (EU) 2016/863 of 31 May 2016 amending Annexes VII and VIII to Regulation (EC) No 1907/2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), Annex VII, ‘8.2. Serious eye damage/eye irritation’ column 2: The study/ies do(es) not need to be conducted if: —the substance is classified as skin corrosion, leading to classification as serious eye damage (Category 1), or — the substance is classified as skin irritation and the available information indicates that it should be classified as eye irritation (Category 2), or —the substance is a strong acid (pH ≤ 2,0) or base (pH ≥ 11,5) and the available information indicates that it should be classified as serious eye damage (Category 1).
These criteria are fulfilled as the pH of diisobutyl phosphate is below pH 2. An eye irritation toxicity study is therefore not required according to CLP criteria and COMMISSION REGULATION (EU) 2016/863 of 31 May 2016 amending Annexes VII and VIII to Regulation (EC) No 1907/2006.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no study available
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
The experimental determined pH-value of diisobutyl phosphate is below pH 2. Therefore, a classification of diisobutyl phosphate as corrosive to skin ( Skin Corr. 1 (H314: Causes severe skin burns and eye damage)) and Eye Damage 1 (H318: Causes serious eye damage) is justified.
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