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EC number: 231-130-8
CAS number: 7440-21-3
Food grade micronized silica gel (SYLOID®) was given in a feed to
B6C3F1 mice and Fisher rats at dose levels of 0, 1.25, 2.5, and 5% (≈ 0,
2,500, 5,000, 10,000 mg/kg/day for mice and 0, 625, 1,250, 2,500
mg/kg/day for rats) for 93 and 103 weeks, respectively (Takizawa et
al. 1988). Measurements: physical examinations and observations,
clinical chemistry, post-mortem examination. There were no biological or
any other meaningful alterations in body weight, food consumption or
physical features of the exposed animals. No significant dose-related
effects were seen at any dose level upon clinical laboratory
examinations. The pathological examinations revealed no gross or
microscopic changes in the tissues examined. The occasional presence of
some neoplasms did not reveal any consistent, dose-related trends in any
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