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EC number: 231-130-8
CAS number: 7440-21-3
Test data on the irritation properties of amorphous silica, which can be used for read-across, do not show eye or skin irritation.
Irritation tests have not been performed
There are data available on the irritant
properties of synthetic amorphous silica. The surface of silicon is
composed of a thin oxidized silicon layer resembling the surface of
amorphous silicon dioxide. Both silicon and amorphous silica release
silicon from particles. The in vitro data on the dissolution
kinetics of silicon in different artificial biological fluids shows that
the solubility of silicon in biological media is similar or lower than
that of amorphous silicon dioxide and it is justified to
use read-across from amorphous silicon dioxide to silicon. A detailed
description of the justifications for read-across is available in
Section 13 of the Iuclid dossier.
According to available data, synthetic
amorphous silica and silicates are not irritating to skin and eyes under
experimental conditions. Industrial data presented in OECD (2004a)
describes dryness of the skin in workers with chronic contact with
precipitated amorphous silica. No cases of skin or eye irritation have
been reported in literature from the ferrosilicon/ silicon manufacturing
industry or on the use of silica fume. Altogether, there is no reason to
believe that silicon would differ in this respect from the sparsely
soluble amorphous silicon dioxide.
Conclusion: Silicon is not likely to
be a skin or eye irritant. No classification or further testing is
proposed. Naturally, like any other dusts, the dusts of silicon may also
cause mechanical irritation of the eye and respiratory tract.
Read-across to synthetic amorphous
silica: irritation tests with synthetic amorphous silica are negative.
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