Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 231-130-8
CAS number: 7440-21-3
Liu et al. (1996) challenged Chinese hamster fibroblasts
with respirable silica particles using an in vitro genotoxicity
assay. Two particle sizes of crystalline quartz and non-crystalline
silica (5 μm Spherisorb®) were assayed for induction of micronuclei
(MN). The results showed that both crystalline and non-crystalline
silica dispersed in medium induced micronuclei formation in a
dose-dependent manner. Induction was seen only at dose levels inducing
cytotoxicity. Crystalline silica was more active in this assay than
non-crystalline silica on a mass basis. The results also show that the
frequency of micronucleated cells in cultures treated with lung
surfactant-coated crystalline silica was not significantly different
from that of the non-treated control cultures. The authors state that
the high observed cytotoxicity might explain the genotoxic effect. The
pre-treatment of silica particles with simulated pulmonary surfactant
reduced cytotoxicity and also reduced or delayed genotoxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Niniejsza strona używa plików cookies, aby zapewnić optymalne korzystanie z naszych stron internetowych.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again