Registration Dossier

Toxicological information

Exposure related observations in humans: other data

Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: extensive evaluation report by OECD
Cross-reference
Reason / purpose:
reference to other study

Data source

Reference
Reference Type:
other: evaluation
Title:
SIDS initial assessment report for SIAM 19. Synthetic amorphous silica and silicates.
Author:
OECD
Year:
2004
Bibliographic source:
UNEP Publications, Berlin.

Materials and methods

Type of study / information:
other: human - medical data / skin contact
Endpoint addressed:
skin irritation / corrosion
Principles of method if other than guideline:
OECD evaluated availabe data on human skin contact with amorphous silica, only one study available,
workers had intensive and regular contact with silica

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Results:
signs of irritation which resulted to skin dryness

Applicant's summary and conclusion

Conclusions:
The adverse effect was reversible.
Executive summary:

OECD (2004) evaluated that there one study on human skin contact with synthetic amorphous silica. More than 200 workers were in conctact with amorphous silica. This resulted to skin dryness which was a reversible effect and was able to be controlled by regular use of skin-protection ointment..