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EC number: 203-904-5
CAS number: 111-75-1
Butylethanolamine was administered
intraperitoneally to 5 NMRI mice per sex and dose at dose levels of
68.1, 100, 147 and 215 µL/kg bw (61, 89, 131 and 192 mg/kg bw -
conversation in mg/kg is based on the density: d= 0.8917 g/cm³) (BASF,
1977). The dilutions of the test substance were prepared in water as
0.681 - 2.15%. The animals were observed for signs of toxicity during 14
days. No animals died at 68.1, 100 µL/kg bw. At 147 µL/kg bw, 1 male and
1 female animal died 48 hours post application; 1 female and 3 male
animals died until the end of the observation period. At 215 µL/kg bw:
all animals died. Body weights of surviving animals decreased. No
clinical signs was observed in 68.1 µL/kg bw dose group. At dose level
of 100 µL/kg bw, irregular respiration and spastic gait were noted. At
147 µL/kg bw, irregular respiration, spastic gait, apathy were observed
immediately after application until the 5th day post exposure; ruffled
fur and tremors on several days. LD50 of >-131 -<192 mg/kg bw was
established in the study.
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