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EC number: 203-904-5
CAS number: 111-75-1
PNECs for the different compartments are calculated either by
application an assessment factor (PNECfreshwater, PNECmarine water,
PNECintermittent release and PNECstp) or using the equilibrium
assumption method (PNECsediment-freshwater,
PNECsediment-marine-water and PNECsoil). The PNECair is not considered
as relevant based on the chemical structure and intrinsic properties of
the registered substance. Secondary exposure of mammals and birds is not
expected, and since no adequate bird or mammalian data are available,
the PNECsecondary poisoning is omitted. The utilized procedures are
described in detail in the ECHA REACH Guidance of May 2008, Chapter R.10
("Characterisation of dose
[concentration]-response for environment").
classification regarding environmental hazards
to Regulation (EC) 1272/2008 Annex VI Table 3.1, the substance is not
classified as hazardous to the environment.
to Regulation (EC) 1272/2008 Annex VI Table 3.2, the substance is not
classified as hazardous to the environment.
GHS, the substance is not to be classified as acutely or chronically
hazardous to the aquatic environment.
substance is not to be classified as acutely hazardous to the aquatic
environment, since the lowest acute effect value is > 1 mg/L.
data are available only for algae. Therefore classification is based on
the available chronic and acute toxicity data.
Chronic toxicity data: Chronic data are available for algae. The
substance is rapidly degradable and the ErC10
(72 h) is >1 mg/L (ErC10 (72 h) 2.4 mg/L).
According to the criteria outlined in Table 4.1.0(b) (ii) (Commission
Regulation (EU) No 286/2011 amending Regulation (EC) No 1272/2008) the
substance is not to be classified as chronically hazardous to the
trophic levels in aquatic toxicology are covered by acute tests. The
substance is not acutely harmful to fish and invertebrates, as the LC50
(96 h) for fish and the EC50 (48 h) for daphnids were determined to be
>100 mg/L and 180 mg/L respectively. Algae turned out to react most
sensitive with an ErC50 of 30 mg/L after 72 hours of exposure. The ErC10
was determined to be 2.4 mg/L and the NOErC was 0.39 mg/L. According to
the Guidance on information requirements and chemical safety assessment
Chapter R.10: Characterisation of dose [concentration]-response for
environment "an EC10 for a long-term test which is obtained using an
appropriate statistical method (usually regression analysis) will be
used preferentially. [...] There has been a recommendation within OECD
in 1996 to phase out the use of the NOEC, in particular as it can
correspond to large and potentially biologically important magnitudes of
effect. The advantage of regression method for the estimation of ECx is
that information from the whole concentration-effect relationship is
taken into account and that confidence intervals can be calculated.
These methods result in an ECx, where x is a low effect percentile (e.g.
5-20%). It makes results from different experiments more comparable than
NOECs." Therefore, the ErC10 instead of the NOErC has been used to
derive the classification.
Acute toxicity data: Fish and invertebrates are the trophic levels not
covered by chronic data. Therefore classification is based on the
respective acute effect data.
L(E)C50 are > 100 mg/L, the substance is rapidly degradable and the log
Pow is < 4. Therefore the substance is not to be classified as
chronically hazardous based on acute toxicity data following the
criteria outlined in Table 4.1.0(b) (III).
the substance is not to be classified as chronically hazardous to the
substance is not to be classified as acutely or chronically hazardous to
the aquatic environment according to Regulation (EC) 1272/2008.
test substance is not in Annex I of Regulation (EC) 2037/2000 on
substances that deplete the ozone layer.
test substance does not belong to the greenhouse gases listed in P
Forster, PV Ramaswamy et al. Changes in Atmospheric Constituents and in
Radiative Forcing. In: Climate Change 2007: The Physical Basis.
Contribution of Working Group I to the Fourth Assessment Report of the
Intergovernmental Panel on Climate Change.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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