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EC number: 233-566-4
CAS number: 10236-47-2
Test item results (30 mg), 14/11/2016.
Corneal swelling (%)
1 x III, 1 x II, 1 x I
No prediction can be made
morphological effects were noted, whatever the examination time.
An in vitro (ex vivo) study was conducted in order to determine the
potential severe eye damaging effects of the test item according to the
OECD guideline 438 under GLP conditions. Eyeballs were isolated from
chickens killed for human consumption and after the appropriate
preparation were exposed to either 30 mg of the test item, 30 mg of
sodium hydroxide (positive control) or 30 µL
of physiological saline (negative control). Three eyeballs were used in
each group. Fluorescein retention, corneal opacity and corneal swelling
were evaluated, then the results of each endpoint were assigned to ICE
classes according to OECD guideline 438. According to the overall in
vitro classification (UN GHS), no prediction can be made since the
combinations of the 3 endpoints for the test item were 1 x III, 1 x II,
1 x I.
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