Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 233-566-4
CAS number: 10236-47-2
Table 1. Relevant pharmacokinetic parameters.
Average ± S.D. (n = 6)
AUC [0-24] (ng/ml h)
A study on the absorption of the test item in rats was performed. A
single dose of 746.7 mg/kg test item was orally administered (by gavage)
to 6 male Sprague Dawley rats, and the concentrations of the test item
and its metabolites were determined in plasma at 0 (predose), 5, 15, 30,
45, 60, 120, 240, 360, 480, 720 and 1440 min after dosing by liquid
chromatography-tandem mass spectrometry (LC-MS/MS). The test item
was quickly absorbed into the body and could be detected 5 min after
oral administration. The Tmax was
45 min. The plasma concentration also declined quickly, within 2 h. Its
metabolites, naringenin and naringenin glucuronide, were produced slowly
after oral administration and Tmax for
them were 9 and 7.5 h, respectively. After 24 h, no test item could be
detected. Based on these results, the test item shows no
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again