Registration Dossier

Administrative data

Endpoint:
repeated dose toxicity: dermal
Remarks:
other: repeated dose toxicity: dermal
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: study not available. (cited in US EPA memorandum dated March 23, 1990).
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1989

Materials and methods

Principles of method if other than guideline:
other: 21 days dermal irritation study
GLP compliance:
yes
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no data

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Type of coverage:
not specified
Vehicle:
other:
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
21 days
Frequency of treatment:
5 days/week
Doses / concentrations
Remarks:
Doses / Concentrations:
300 mg/kg/day
Basis:

No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Effect levels

Basis for effect level:
other: see: executive summary
Remarks on result:
not measured/tested
Remarks:
Effect level not specified (migrated information)

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

no significant dermal irritation was observed

Applicant's summary and conclusion

Executive summary:

A 21 -day dermal toxicity study (GLP) in SD rats up to 300 mg/kg/day of 1,4 -dichlorobenzene in mineral oil, failed to elicit any toxic effects or significant dermal irritation but the highest dose tested did nor reflect a limit dose.