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Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No particle size of Paradichlorobenzene mentioned.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1987
Report date:
1987

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Principles of method if other than guideline:
The acute inhalation toxicity of p-dichlorobenzene was assessed by exposing 10 rats for a period of 4 hours to vapour produced by passing air through the test substance; control group was included. After termination of the observation period of 14 days the animals were sacrificed and subjected to macroscopic examination.
GLP compliance:
yes (incl. QA statement)
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Reference substance name:
Paradichlorobenzene Lot 08146-P (A)
IUPAC Name:
Paradichlorobenzene Lot 08146-P (A)
Constituent 2
Chemical structure
Reference substance name:
1,4-dichlorobenzene
EC Number:
203-400-5
EC Name:
1,4-dichlorobenzene
Cas Number:
106-46-7
Molecular formula:
C6H4Cl2
IUPAC Name:
1,4-dichlorobenzene
Test material form:
solid: crystalline
Details on test material:
p-dichlorobenzene, lot: 08146-P
content 99.9 %

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals or test system and environmental conditions:
10 male rats at the age of 6 weeks.
10 female rats at the age of 8 weeks.
These ages of rats were selected so that the males and females were at similar bodyweight (ca. 200g).
Housing : in groups of 5
acclimisation pereiod: 5 days
room temperature: 21-22 °C
relative humidity: 48-50 %

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
air
Details on inhalation exposure:
5 male and 5 female rats were exposed continously for 4 hours to a test atmosphere containing vapour from the test substance.
another 5 male and 5 female rats acting as a control received clean air only for 4 hours.
Analytical verification of test atmosphere concentrations:
yes
Duration of exposure:
4 h
Concentrations:
control group and a test group exposed to 5,07 mg/l atmosphere concentration of Paradichlorobenzene vapour.
No. of animals per sex per dose:
5 male and 5 female rats.
Control animals:
yes
Details on study design:
The acute inhalation toxicity of p-dichlorobenzene was assessed by exposing 10 rats for a period of 4 hours to vapour produced by passing air through the test substance; control group was included. After termination of the observation period of 14 days the animals were sacrificed and subjected to macroscopic examination.
Statistics:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 5.07 mg/L air
Exp. duration:
4 h
Remarks on result:
other: unspecific reactions to exposure, recovery within 1 day, no animal died
Mortality:
There were no deaths during the study.
Clinical signs:
other: Signs during exposure: closing of eyes, wetness around the mouth, fluid discharge from the mouth, exagerated respiratory movements. Signs during observation period: increased respiration rate, wet fur around snout and jaws, yellow staining around the urog
Body weight:
small losses in body weight were observed in all rats exposed to paradichlorbenzene for 1 day following exposure. Subsequently weight gain was
similar to that of the control rats.
Gross pathology:
The lung weight to body weight ratio for all rats was within the normal limit. ther were no abnormalities in th rats.

Any other information on results incl. tables

There were no deaths following an acute inhalation toxicity 4- hour exposure to vapour with paradichlorobenzene.

Applicant's summary and conclusion

Executive summary:

The acute inhalation toxicity of p-dichlorobenzene was assessed by exposing 10 rats for a period of 4 hours to 5070 mg/m³ vapour produced by passing air through the test substance; control group was included. The test precedure was equivalent to OECD TG 403 and performed under GLP condions. After termination of the observation period of 14 days the animals were sacrificed and subjected to macroscopic examination. Immediately following exposure an increased respiration rate was seen. This and other minor signs disappeared by the day following exposure and subsequently all rats were normal. No animal died.

The LC50 of paradichlorobenzene in rat was found to be greater than 5,07 mg/l air (5070 mg/m³ air).