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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

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Diss Factsheets

Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No GLP defined.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1988
Report date:
1988

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
1,4-dichlorobenzene
EC Number:
203-400-5
EC Name:
1,4-dichlorobenzene
Cas Number:
106-46-7
Molecular formula:
C6H4Cl2
IUPAC Name:
1,4-dichlorobenzene
Test material form:
other: solid
Details on test material:
IUCLID4 Test substance: as prescribed by 1.1 - 1.4
content: 99.9 %

Test animals

Species:
rabbit
Strain:
New Zealand White
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 3,4- 3,5 kg.
- Housing: individually
- Diet ad libitum
- Water ad libitum
- Acclimation period: 14 days

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20
- Humidity (%): 50
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light): 12 / 12

Test system

Type of coverage:
semiocclusive
Preparation of test site:
other: clipped
Vehicle:
other: parafine oil
Controls:
other: the contralateral side was untreated and served as control
Amount / concentration applied:
500 mg paradichlorbenzene moistened with parafine oil on a 6 cm² skin surface.
Duration of treatment / exposure:
4 hours.
Observation period:
7 days
Number of animals:
3
Details on study design:
500 mg paradichlorbenzene moistened with parafine oil was applied on a 6 cm² skin surface of the back of 3 rabbits covered with a semiocclusive plaster for 4 hours (the contralateral side was untreated and served as control). After termination of treatment the respective areas were washed with water and observed for 7 days

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 24-72 hours
Score:
>= 0.7 - <= 1
Max. score:
4
Reversibility:
fully reversible within: 7 days
Irritation parameter:
edema score
Basis:
mean
Time point:
other: total observation time
Score:
ca. 0
Max. score:
4
Irritant / corrosive response data:
Based on the observed erythema score of 1 of max 4(in 2 rabbits at 24,48,72 h and 1 rabbit at 48 and 72 h) which recovered within 7 days and no edema during the total observation time , the test substance is evaluated as slightly irritating to the skin of rabbits which do not lead to classification

Any other information on results incl. tables

No edema observed.

   Draize grade after        
   1h 24h  48h  72h  7d 
  Erythema   Erythema    Erythema    Erythema    Erythema  
Rabbit 1   1  1  1
Rabbit 2 0  1  1  0
Rabbit 3   0  1  1  0

Applicant's summary and conclusion

Interpretation of results:
slightly irritating
Remarks:
Migrated information
Executive summary:

Skin irritation was tested using the OECD TG 404 in rabbits.500 mg paradichlorbenzene moistened with parafine oil was applied on a 6 cm² skin surface of the back of 3 rabbits covered with a semiocclusive plaster for 4 hours (the contralateral side was untreated and served as control). After termination of treatment the respective areas were washed with water and observed for 7 days. p-Dichlorobenzene evoked no systemic reactions but slight and passagere erythema on skin of adult rabbits (total irritation score: 0.7- 1.0 with total recovery within 7 days and no edema). These very mild skin reactions can be evaluated as no acute risk potential for skin of rabbits and do not lead to classification or labelling