Registration Dossier

Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No OECD guideline or GLP study defined.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1989

Materials and methods

Principles of method if other than guideline:
Metghod: other
GLP compliance:
not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
Fischer 344
Sex:
male

Administration / exposure

Route of administration:
other: gavage
Vehicle:
other: corn oil
Doses:
500 mg/kg
No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Any other information on results incl. tables

see: executive summary

Applicant's summary and conclusion

Executive summary:

After single oral administration of 770 mg/kg 1,4 -dichlorobenzene, an increase in the formation of hyaline droplets in the renal cortex was observed in male rats.