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Toxicological information

Exposure related observations in humans: other data

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Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
other: observations in humans
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: observation in humans

Data source

Reference
Reference Type:
publication
Title:
Toxicity of Paradichlorobenzene- Determination on Animals and Human Subjects
Author:
Hollingsworth R.L.
Year:
1956
Bibliographic source:
Arch.Industr.Health, 14, 1956

Materials and methods

Type of study / information:
observation in humans
Endpoint addressed:
eye irritation
Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
observation in humans: 58 workers, 8 hours /day 5 days/week, for 8 months up to 25 years
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: solid
Details on test material:
no further data

Method

Ethical approval:
not applicable
Details on study design:
observations in humans

Results and discussion

Results:
Industrial workers which were indefinitely exposed to 10 -550 ppm (92 -3366 mg/m³) p-DCB did not announce any disturbances at 15 -85 ppm (average: 45 ppm; 92 -520 mg/m³, average 275 mg/m³). At 50 -170 ppm (average 105 ppm; 306 -1040 mg/m³; average 643 mg/m³) the workers specified irritations of eyes and nose. These effects were more severe at 160 ppm (979 mg/m³) p-DCB. At 15 -30 ppm a slight smell was noticed, which was strong at 30 -60 ppm. At higher concentrations the smell was not tolerable.
The NOAEC therefore is <50 ppm.

Applicant's summary and conclusion