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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Exposure related observations in humans: other data

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Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
other: observations in humans
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: observation in humans

Data source

Reference
Reference Type:
publication
Title:
Toxicity of Paradichlorobenzene- Determination on Animals and Human Subjects
Author:
Hollingsworth R.L.
Year:
1956
Bibliographic source:
Arch.Industr.Health, 14, 1956

Materials and methods

Type of study / information:
observation in humans
Endpoint addressed:
eye irritation
Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
observation in humans: 58 workers, 8 hours /day 5 days/week, for 8 months up to 25 years
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1,4-dichlorobenzene
EC Number:
203-400-5
EC Name:
1,4-dichlorobenzene
Cas Number:
106-46-7
Molecular formula:
C6H4Cl2
IUPAC Name:
1,4-dichlorobenzene
Test material form:
other: solid
Details on test material:
no further data

Method

Ethical approval:
not applicable
Details on study design:
observations in humans

Results and discussion

Results:
Industrial workers which were indefinitely exposed to 10 -550 ppm (92 -3366 mg/m³) p-DCB did not announce any disturbances at 15 -85 ppm (average: 45 ppm; 92 -520 mg/m³, average 275 mg/m³). At 50 -170 ppm (average 105 ppm; 306 -1040 mg/m³; average 643 mg/m³) the workers specified irritations of eyes and nose. These effects were more severe at 160 ppm (979 mg/m³) p-DCB. At 15 -30 ppm a slight smell was noticed, which was strong at 30 -60 ppm. At higher concentrations the smell was not tolerable.
The NOAEC therefore is <50 ppm.

Applicant's summary and conclusion