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Toxicological information

Additional toxicological data

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Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
other: Mechanistic studies: hepatotoxicity
Rationale for reliability incl. deficiencies:
other: Mechanistic studies: hepatotoxicity

Data source

Referenceopen allclose all

Title:
No information
Author:
Allis, J.W. et al. (1989): Toxicologist 9, 171
Title:
No information
Author:
Allis, J.W. et al. (1992): J. Biochem. Toxicol. 7, 257 - 264
Title:
No information
Author:
Brodie, B.B. et al. (1971): Proc. Nat. Acad. Sci. 68, |160 - 164
Title:
No information
Author:
Gunawardhana, L. et al. (1990): Toxicologist 10, 298
Title:
No information
Author:
Reid, W.D. (1973): Proc. 5th Int. Congr. Pharmacol., |San Francisco 1972, 2, 62 - 74
Title:
No information
Author:
Reid, W.D. et al. (1973): Pharmacology 10, 193 - 214
Title:
No information
Author:
Reid, W.D., Krishna, G. (1973): Exp. Mol. Pathol. 18, |80 - 99
Title:
No information
Author:
Stine, E.R. et al. (1991): Toxicol. Appl. Pharmacol. 109,|472 - 481
Title:
No information
Author:
Umemura T.,et al. (1998):Drug and Chemical Toxicology, 21(1), 57-66 Umemura T, et al.(1996):Toxicology and Applied Pharmacology 137, 268-274 Umemura T., et al.(1992): Arch.Toxicol.66: 503-507

Materials and methods

Type of study / information:
Type: other: Hepatoxicity
Principles of method if other than guideline:
other: Mechanistic studies: hepatotoxicity
GLP compliance:
not specified
Remarks:
other: Mechanistic studies: hepatotoxicity

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
other: Mechanistic studies: hepatotoxicity

Results and discussion

Any other information on results incl. tables

other: Mechanistic studies: hepatotoxicity

Applicant's summary and conclusion

Executive summary:

other: Mechanistic studies: hepatotoxicity