Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-634-3 | CAS number: 144-62-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Oxalic acid dihydrate
- Cas Number:
- 6153-56-6
- Molecular formula:
- C2O4H2.2H2O
- IUPAC Name:
- Oxalic acid dihydrate
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Duration of treatment / exposure:
- General conditions of the animals have been daily observed.
The eyes have been examined after 1, 24, and 48 hours, from the beginning of the study by means of
an ophthalmoscope. - Observation period (in vivo):
- 21 days
- Number of animals or in vitro replicates:
- 1
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- other: 1 h
- Score:
- ca. 2
- Max. score:
- 2
- Reversibility:
- not reversible
- Remarks on result:
- other:
- Remarks:
- A previous check after 1 h was carried out
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- ca. 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 48 h
- Score:
- ca. 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 72 h
- Remarks on result:
- not measured/tested
- Remarks:
- Evidence of results at 48 h made determination at 72 h unnecessary
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- other: 1 h
- Score:
- ca. 1
- Max. score:
- 1
- Reversibility:
- not reversible
- Remarks on result:
- other:
- Remarks:
- A previous check after 1 h was carried out
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- ca. 2
- Max. score:
- 2
- Reversibility:
- not reversible
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- 48 h
- Score:
- ca. 2
- Max. score:
- 2
- Reversibility:
- not reversible
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- 72 h
- Remarks on result:
- not measured/tested
- Remarks:
- Evidence of results at 48 h made determination at 72 h unnecessary
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: 1 h
- Score:
- ca. 3
- Max. score:
- 3
- Reversibility:
- not reversible
- Remarks on result:
- other:
- Remarks:
- A previous check after 1 h was carried out
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- ca. 3
- Max. score:
- 3
- Reversibility:
- not reversible
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- 48 h
- Score:
- ca. 3
- Max. score:
- 3
- Reversibility:
- not reversible
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- 72 h
- Remarks on result:
- not measured/tested
- Remarks:
- Evidence of results at 48 h made determination at 72 h unnecessary
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- other: 1 h
- Score:
- ca. 3
- Max. score:
- 3
- Reversibility:
- not reversible
- Remarks on result:
- other:
- Remarks:
- A previous check after 1 h was carried out
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- ca. 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 48 h
- Score:
- ca. 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 72 h
- Remarks on result:
- not measured/tested
- Remarks:
- Evidence of results at 48 h made determination at 72 h unnecessary
- Other effects:
- Cornea: 60 minutes after treatment translucent area were easily discernible and details of iris were slightly obscured. 24 hours later cornea appeared opaque and iris wasn’t discernible through the opacity
Iris: 60 minutes after treatment were observed congestion and swelling, iris was reactive to light (a sluggish reaction). 24 hours later iris wasn’t discernible through the cornea opacity
Conjunctivae:
(Congestion) 60 minutes after the treatment the conjunctivae appeared of a diffuse beefy red. The ymptom persisted for all observation time.
Conjunctivae:
(Chemosis) 60 minutes after treatment the conjunctivae showed a swelling with lids about half closed. 24 hours later a swelling, with lids more than half closed.
Any other information on results incl. tables
Eye reactions have been evaluated according to the values reported in the following table:
CORNEA
Opacity - degree of density (the most dense area is chosen for the evaluation)
No ulceration or opacity 0
sporadic or diffused areas of opacity (different from the slight opacity of normal luminosity)
details of iris clearly visible 1
Easily discernible translucent area, details of iris slightly obscured 2
Iridescent area, no details of iris visible, size of pupil barely discernible 3
Opaque cornea, iris not discernible through opacity 4
IRIS
Normal 0
Notably opened rugae, congestion, swelling, moderate circumcorneal
hyperaemia, or injection, any of these effects or a combination of them, iris stil
reacting to light (slow reaction is positive) 1
No reaction to light, haemorrhage, macroscopic injuries (any or all of these) 2
CONJUNCTIVAE
Redness (refers to palpebral and bulbar conjunctivae, cornea and iris)
Normal blood vessels 0
Some blood vessels definitely hyperaemic (congested) 1
Diffuse, crimson colour, individual vessels not easily discernible 2
Diffuse beefy red 3
Chemosis: lids and/or nictitating membranes
No swelling 0
Any swelling above normal (includes nictitating membrane 1
Obvious swelling with partial ectoprion 2
Swelling with lids about half closed 3
Swelling with lids more than half closed 4
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- On the basis of the results, interpreted according to Official Journal of the European Union 1272/2008
(CLP) dated December 16th, 2008 and OECD n° 405 April 24th 2002, the test substance “OXALIC
ACID” causes IRREVERSIBLE EFFECTS ON THE EYE and must be included in CATEGORY 1.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.