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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
no data
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: scientifically acceptable.

Data source

Reference
Reference Type:
publication
Title:
Acute toxicity and skin corrosion data for some organic and inorganic compounds and aqueous solutions
Author:
Vernot, E.H., MacEwen, J.D., Haun, C.C., Kinkead, E.R.
Year:
1977
Bibliographic source:
Toxicology and Applied Pharmacology, Vol 42, p 417-423

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Single oral dose toxicity determined by the method of Smyth et al. (1962), no details on method provided.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Oxalic acid
EC Number:
205-634-3
EC Name:
Oxalic acid
Cas Number:
144-62-7
Molecular formula:
C2H2O4
IUPAC Name:
oxalic acid

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
water
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Effect levelsopen allclose all
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
9.5 mL/kg bw
95% CL:
>= 5.4 - <= 12.3
Remarks on result:
other: 475 mg/kg bw
Key result
Sex:
female
Dose descriptor:
LD50
Effect level:
7.5 mL/kg bw
95% CL:
>= 5 - <= 11
Remarks on result:
other: 375 mg/kg bw
Clinical signs:
other:

Any other information on results incl. tables

The following table is reproduced from the publication. Only the relevant part concerning oxalic acid is reproduced.

Material studied

Single oral LD50

Male rats

Other

Oxalic acid (5%)

9.5 (5.4-12.3) [mL/kg]

7.5 (5.0-11.0) [mL/kg] (females)

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
In a single oral toxicity test with a 5% aqueous solution of oxalic acid, an LD50 of 9.5 mL/kg (475 mg/kg bw) was determined in male rats, and an LD50 of 7.5 mL/kg (375 mg/kg bw) was determined in female rats, under the current test conditions.
Executive summary:

In this study, the single oral dose toxicity of 110 organic and inorganic compounds, including oxalic acid, was tested. For a 5% aqueous solution of oxalic acid, an LD50 of 9.5 mL/kg was determined in male rats, and an LD50 of 7.5 mL/kg was determined in female rats, under the current test conditions.