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Description of key information

Key value for chemical safety assessment

Skin sensitisation

Link to relevant study records
Reference
Endpoint:
skin sensitisation: in vivo (LLNA)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Qualifier:
according to
Guideline:
OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of study:
mouse local lymph node assay (LLNA)
Species:
mouse
Strain:
CBA
Sex:
female
Vehicle:
dimethyl sulphoxide
Concentration:
12.5%, 25% and 50%
No. of animals per dose:
3 test groups of 5 animal (3 different concentrations).
Parameter:
SI
Remarks on result:
other: see Remark
Remarks:
None of the 3 concentrations tested reached the stimulation index of 3: The stimulation index at a concentration of 12.5% was of 2.6 The stimulation index at a concentration of 25% was of 1.9 The stimulation index at a concentration of 50% was of 2.5
Interpretation of results:
not sensitising
Remarks:
Migrated information
Conclusions:
The EC3 value (derived by linear interpolation) could not be calculated as the
stimulation indices of all concentrations were below 3.
Consequently, according to OECD 429 and the criteria given in Annex I of Regulation (EC) 1272/2008, the test item Oxalic Acid, as described in this report is expected to have no sensitising properties and therefore, should not be regarded as a dermal sensitiser
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)

Justification for classification or non-classification