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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
no data
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: scientifically acceptable.
Qualifier:
no guideline followed
Principles of method if other than guideline:
Single oral dose toxicity determined by the method of Smyth et al. (1962), no details on method provided.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no
Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Route of administration:
oral: unspecified
Vehicle:
water
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
9.5 mL/kg bw
95% CL:
>= 5.4 - <= 12.3
Remarks on result:
other: 475 mg/kg bw
Key result
Sex:
female
Dose descriptor:
LD50
Effect level:
7.5 mL/kg bw
95% CL:
>= 5 - <= 11
Remarks on result:
other: 375 mg/kg bw
Clinical signs:
other:

The following table is reproduced from the publication. Only the relevant part concerning oxalic acid is reproduced.

Material studied

Single oral LD50

Male rats

Other

Oxalic acid (5%)

9.5 (5.4-12.3) [mL/kg]

7.5 (5.0-11.0) [mL/kg] (females)
Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
In a single oral toxicity test with a 5% aqueous solution of oxalic acid, an LD50 of 9.5 mL/kg (475 mg/kg bw) was determined in male rats, and an LD50 of 7.5 mL/kg (375 mg/kg bw) was determined in female rats, under the current test conditions.
Executive summary:

In this study, the single oral dose toxicity of 110 organic and inorganic compounds, including oxalic acid, was tested. For a 5% aqueous solution of oxalic acid, an LD50 of 9.5 mL/kg was determined in male rats, and an LD50 of 7.5 mL/kg was determined in female rats, under the current test conditions.

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
375 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available
Quality of whole database:
Data waiving

Acute toxicity: via dermal route

Link to relevant study records
Reference
Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: authoritative database and European Agency Report.
Qualifier:
no guideline followed
Principles of method if other than guideline:
No
GLP compliance:
no
Species:
rabbit
Key result
Dose descriptor:
LD50
Effect level:
20 000 mg/kg bw
Clinical signs:
other:
Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
Despite the result of the reported study, the substance is classified as harmful in contact with the skin, according to Harmonised classification - Annex VI of Regulation (EC) No 1272/2008 (CLP Regulation)
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
20 000 mg/kg bw

Additional information

Justification for classification or non-classification