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EC number: 700-990-0
CAS number: -
This study was performed to determine the developmental toxicity
potential of Santicizer 154 in rats. Gravid rats were exposed during
GD6-19 to 0, 300, 1000 or 3000 mg/kg bw/day. Clinical signs, mortality
and body weights were recorded. Gross necropsy and uterine examination
in the dams was performed, as well as external, visceral and skeletal
malformations in the fetuses.
Clinical signs were reported troughout all groups, including the control
group. Statistically significant decrease noted in the mean number of
early resorptions and mean postimplantation loss in the mid-dose group,
but this was attributed to random occurrence. Slight increase in number
of litters with malformations in the 3000 mg/kg bw/day group, but this
was not considered biologically relevant as the malformations occurred
as single incidences.
Under the conditions of this study, no biologically significant effects
were observed in rats exposed to Santicizer 154 during day 6-19 of
gestation or their litter. Therefore, a NOAEL of 3000 mg/kg bw/day was
established for both developmental and maternal toxicity.
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