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EC number: 700-990-0
CAS number: 68937-40-6
- Mortality: No treatment related effects observed
- Clinical signs: Ruffed and discolored fur and ptosis in test groups.
High dose group animals exhibited rhinitis, sneezing, wheezing and
- Body weight: No difference as compared to the control group
- Hematology: No difference as compared to the control group
- Clinical chemistry: No treatment related effects observed
- Urinalysis: No difference as compared to the control group
- Gross necropsy: No difference as compared to the control group
- Organ weights: Males of the highest dose group had significant higher
relative liver weight as compared to control males. No other
toxicogically significant effects were found.
- Gross/histopathology: No difference as compared to control group
The toxicity of Santicizer 154 was determined in a 90-day inhalation
study in rats. Male and female animals were exposed for 6 hours a day, 5
days a week over a period of 90 days (total 62 exposure days) to 0, 10.1
or 101.1 mg/m3 of test article. Mortality, clinical signs, body weights
were recorded and gross necropsy was performed in all animals.
Hematology, clinical chemistry, urinalysis and histopathology were
performed and organ weights were recorded in the high dose and control
No test article-related deaths were noted. A ruffed and discolored fur
and ptosis in both test groups, while in the high dose group animals
exhibited rhinitis, sneezing, wheezing and hemorrahic conjunctivitis. No
difference in body weights, hematology parameters, clinical chemistry
values and urinalysis parameters were observed as compared to the
control group. Gross necropsy showed no differences in both test groups
as compared to the control group. Males of the highest dose group had a
significant higher relative liver weight as compared to control males.
No other toxicologically significant effects were found. No treatment
related histopathological effects were observed in the highest dose
group as compared to the control group.
Under the conditions of this study, no clear test article- or
dose-related effects were observed in rats as a result of exposure to
Santicizer 154. Therefore, a NOAEL of 101.1 mg/m3 was established.
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