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EC number: 700-990-0
CAS number: 68937-40-6
The test compound was examined for
mutagenic activity in a series of in vitro microbial assays employing S.
typhimurium TA1535, TA1537, TA1538, TA98 and TA100, and Saccharomyces
cerevisiae D4. The test was conducted similar to OECD Guideline 471.The
compound was tested directly and in the presence of liver microsomal
enzyme preparations from Aroclor-1254-induced rats. The
compound was tested over a series of concentrations such that there was
either quantitative or qualitative evidence of some chemically-induced
physiological effect at the highest dose level. This, however, could not
be checked. The low dose in all cases was below a concentration that
demonstrated any toxic effect. The concentrations used were 0.01, 0.1,
1.0, 5.0, and 10 ul/plate.
The results of the tests conducted on
the compound in the absence and in the presence of a metabolic
activation system were all negative. The test compound, S-154 Lot
QH-30701 B0-78-82, did not demonstrate genetic activity in any of the
assays conducted in this evaluation and was considered not mutagenic
under these test conditions.
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