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EC number: 700-990-0
CAS number: 68937-40-6
Test diet analysis revealed that the actual concentration of the test
substance in the diet was 92-97% of the theoretical concentration.
Phosflex 51B was administered to rats in concentrations of 0, 100, 400
and 1600 ppm by diet (= mg/kg food). Mortality, clinical signs, body
weight and food consumption were recorded. In addition, hematology,
clinical chemistry, neurotoxicity and histopathology were studied.
No treatment related mortality and clinical signs were noted in the
animals. The statistically significant differences in hematology and
clinical chemistry values and in red blood cell, plasma and brain
cholinesterase activities between control and treated animals were
minimal, inconsistent and considered not to be of biological
significance. A biologically significant increase in liver and adrenal
weights (only females) was noted in the high-dose groups, but this was
not regarded as a toxic and therefore not an adverse effect.
Under the conditions of this study, the 90-day administration of
Phosflex 51B by diet in rats showed to induce no adverse effects.
Therefore, a NOAEL of 107.5 and 124.8 mg/kg bw/day (equivalent to 1600
ppm) was established for males and females, respectively.
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