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EC number: 700-990-0
CAS number: -
Delayed Neurotoxicity of Organophosphorus Substances Following Acute Exposure; Limit test (Protocol for acute delayed neurotoxicity studies: Section 163.81-7, U.S. Environmental Protection Agency's proposed guidelines [Federal Register 43 (163): 37362-37363, 1978]; similar to OECD 418): NOAEL (neurotoxicity): ≥ 11679 mg/kg bw/day (nominal); no neurotoxic potential.
In the key study, the acute delayed neurotoxicity of t-BuTPP was
investigated in an acute, oral, limit test (similar to OECD 418). 15
adult hens were treated with 11.7 g/kg Phosflex 51B, administered on day
1 and after three weeks. Hens were observed for six weekd. No treatment
related effects were observed. It is therefore concluded that the test
compound did not induce the neuropathologic alterations characteristic
of delayed neurotoxicity in the hen. The NOAEL for neurotoxicity, based
on adverse effects, neurobehaviour; neuropathology was ≥11679
Two supporting studies, with no detailed test methods, were available
for neurotoxicity. In both studies, no significant effects were
observed, and it was concluded that t-BuTPP does not have neurotoxic
Based on the available
data, there is no evidence of neurotoxic effects for t-BuTTP. Therefore,
based on the EU criteria outlined in 67/548/EEC and 1272/2008/EC t-BuTPP
does not have to be classified with regard to neurotoxicity.
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