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EC number: 203-652-6
CAS number: 109-16-0
Negative controls in the rat liver
microsome experiments included incubations with heat-inactivated
microsomes, no microsomes and no NADPH. Removal of NADPH made little or
no difference in hydrolysis rates. Heat inactivation significantly
reduced hydrolysis rates, and absence of microsomes resulted in no
TREGDMA was rapidly
converted to MAA in whole rat blood and rat liver microsomes with
hydrolysis half-lives of 3.01 min (liver microsomes) and 5.68 min
This in vitro metabolism study was conducted
to investigate in vitro hydrolysis rates of TREGDMA. Half-lifes were
determined in rat liver microsomes and whole rat blood.
TREGDMA was rapidly converted to MAA in
whole rat blood and rat liver microsomes with hydrolysis half lives of
3.01 min (liver microsomes) and 5.68 min (blood).
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