Registration Dossier

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment
Remarks:
Article in Russian. Only abstract in English.

Data source

Reference
Reference Type:
publication
Title:
ГИГИЕНИЧЕСКОЕ ОБосновАНИЕ ПРЕДЕЛЬНО ДОПУСТИМОЙ КОНЦЕНТРАЦИИ ТРИЭТИЛЕНГЛИКОЛЬДИМЕТАКРИЛАТА В ВОДЕ ВОДОЕМОВ (Hygienic justification of maximum permitted concentrations of TREGDMA in water reservoirs)
Author:
Manenko AK et al.
Year:
1982
Bibliographic source:
Gigiena i Sanitarija, 47(4), 1982

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
no data on guideline available
GLP compliance:
no
Test type:
other: no data on testing procedure

Test material

Constituent 1
Chemical structure
Reference substance name:
2,2'-ethylenedioxydiethyl dimethacrylate
EC Number:
203-652-6
EC Name:
2,2'-ethylenedioxydiethyl dimethacrylate
Cas Number:
109-16-0
Molecular formula:
C14H22O6
IUPAC Name:
2-(2-{2-[(2-methylprop-2-enoyl)oxy]ethoxy}ethoxy)ethyl 2-methylprop-2-enoate
Details on test material:
Purity not specified, but commercial grade assumed.
Specific details on test material used for the study:
- Name of test material (as cited in study report): ТРИЭТИЛЕНГЛИКОЛЬДИМЕТАКРИЛАТ (Trietilenglikoldimetacrilat), TGM-3
- Physical state: liquid
- Analytical purity: no data
- Impurities (identity and concentrations): technical TGM-3: 3,5% Toluene, 0,071% Hydroquinone; treated TGM-3: 0,0043% Hydroquinone
- Purity test date: no data
- Lot/batch No.: no data
- Expiration date of the lot/batch: no data
- Stability under test conditions: no data
- Storage condition of test material: no data

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
10 750 mg/kg bw
Based on:
not specified
Remarks on result:
other: mice

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Conclusions:
The acute oral LD50 of TREGDMA is reported to be 10750 mg/kg bw in mice.
Executive summary:

The acute oral LD50 of TREGDMA is reported to be 10750 mg/kg bw in mice.