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EC number: 203-652-6
CAS number: 109-16-0
In a valid guideline study acc. to OECD 413
( Subchronic inhalation toxicity: 90 day exposure of rats), methacrylic
acid induced signs of general toxicity as indicated by descreased body
weight, body weight gain, food consumption and transiently food
efficiency in the high concentration male animals. At a concentration as
high as 350 ppm (1232 mg/m³), the local irritating effect was marginal,
indicated by the hypertrophy/hyperplasia of the respiratory epithelium
in the nasal cavity of two female animals. Substance-related changes of
the sexual organs were not noted in any of the exposed animals, nor were
there any changes of sperm mobility and sperm head counts. Under the
current test conditions, the no-observed adverse effect level (NOAEL) for
both, local and systemic effects, in this study is 100 ppm (352 mg/m³)
for male and female rats.
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