Registration Dossier

Administrative data

Endpoint:
dermal absorption
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2013

Materials and methods

Principles of method if other than guideline:
The physico chemical parameters of MW, Log P and saturated aqueous solubility have been used in the evaluation of 56 methacrylate compounds. An output of predicted steady-state flux was calculated using the principles defined in the Potts and Guy prediction model. (Potts RO and Guy RH (1992). Predicting Skin Permeability. Pharm. Res. 9(5): 663- 669)
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid
Specific details on test material used for the study:
- Name of test material (as cited in study report): Triethyleneglycol dimethacrylate

Test animals

Details on test animals and environmental conditions:
not applicable; in silico modelling

Administration / exposure

Type of coverage:
other: not applicable; in silico modelling
No. of animals per group:
not applicable; in silico modelling

Results and discussion

Absorption in different matrices:
predicted flux 4.989 μg/cm²/h; the relative dermal absorption is low

Any other information on results incl. tables

Based on a molecular weight of 286.32 g/mol and a log Kow of 2.3, the predicted flux of TREGDMA is 4.989 μg/cm²/h; the relative dermal absorption is low.

Applicant's summary and conclusion

Conclusions:
The dermal absorption of TREGDMA is predicted to be low; the predicted flux is 4.989 μg/cm²/h.
Executive summary:

The dermal absorption (steady-state flux) of TREGDMA has been estimated by calculation using the principles defined in the Potts and Guy prediction model.

Based on a molecular weight of 286.32 g/mol and a log Kow of 2.3, the predicted flux of TREGDMA is 4.989 μg/cm²/h; the relative dermal absorption is low.