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EC number: 203-652-6
CAS number: 109-16-0
Vehicle: acetone/olive oil (4+1 v/v)
Test item concentration
DPM values measured
DPM-BG per animal(2 lymph nodes)a)
1 = Control
a) = values corrected for mean background value (BGI
b) = Stimulation
Indices relative to the mean of the control group (Group 1)
vaild dermal sensitisation study according to OECD Guideline 429
(adopted July 2010) Triethyleneglycol dimethacrylate (purity: 99.68%) in
acetone:olive oil (4+1, v/v), groups of 5 female CBA/CaOlaHsd mice were
tested using the LLNA method with the individual approach.
Local Lymph Node Assay Triethyleneglycol dimethacrylate is a dermal
findings were observed during the study period. Only the highest
dose (100%) induced slight erythema on the ear skin on days 3 to 6
(Score 1). Animals treated with 25 and 50% of the test item did not show
any signs of local skin irritation.
weight of the animals, recorded prior to the first application and prior
to treatment with 3HTdR, was within the range commonly recorded for
animals of this strain and age. No
cases of mortality were observed.
INDICES (S.I.) of 1.40, 1.51 and 3.30 were determined with the test
substance at concentrations of 25%, 50% and 100% (w/v) in acetone:olive
oil (4+1, v/v), respectively. The positive control substance was α-Hexylcinnamaldehyde,
which gave an EC3 at 9.3 % (w/v). A result is regarded as positive when
the S.I. is ≥3.
these criteria, the test substance was found to be a sensitiser.
The EC3 was calculated to be 91.6 %.
study, Triethyleneglycol dimethacrylate is a dermal sensitiser.
GHS (Regulation (EC) No 1272/2008) classification: sensitizing category
1B (EC3 value > 2%)
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