Registration Dossier

Toxicological information

Carcinogenicity

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Administrative data

Description of key information

The available read across data and available weight of evidence demonstrate that Hydrocarbons, C17-C19, n-alkanes, <2% aromatics is highly unlikely to be carcinogenic and is not classifiable as a carcinogen. Further testing is not required under Annex XI, section 1.2.

Key value for chemical safety assessment

Carcinogenicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no study available

Carcinogenicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Carcinogenicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

These findings do not warrant the classification of Hydrocarbons, C17-C19, n-alkanes, <2% aromatics as a carcinogen under the CLP Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures.

Additional information

Hydrocarbons, C17-C19, n-alkanes, <2% aromatics is not genotoxic and is not classifiable as a mutagen based upon the results of reliable read across in vitro and in vivo studies. In bacterial reverse mutation studies, Hydrocarbons, C14-C17, n-alkanes, <2% aromatics and Hydrocarbons, C14-C18, n-alkanes, isoalkanes, cyclics, <2% aromatics were not mutagenic in the presence or absence of metabolic activation . In mammalian cells in vitro there were no mutagenic, clastogenic or aneugenic effects reported in read-across from studies on hydrodesulfurized kerosene; a negative chromosome aberration (Human Peripheral Lymphocyte Chromosomal Aberration Test, Chinese Hamster Ovary Sister Chromatid Exchange Assay).