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EC number: -
CAS number: -
data is being read across from the source study that tested
Hydrocarbons, C11-C14, n-alkanes, < 2% aromatics based on analogue read
A Magnusson and Kligman Guinea-Pig
Maximization test was conducted on 30 guinea pigs with MRD-83-206.
Following a preliminary irritation test, 15 guinea pigs were treated by
intradermal injection (5.0% (v/v) vehicle or adjuvant/ MRD-83-206) to
induce sensitization and then further sensitized by dermal application
of 100.0% (v/v) MRD-83-206. Guinea Pigs were challenged by topical
application (0.5% (v/v) MRD-83-206 in corn oil). All animals survived to
termination of study displaying an increase in weight over the initial
values. There was a very low incidence of clinical
in-life observations noted throughout the test period. Following
topical challenge with 0.5% MRD-83-206, four out of 15 animals in both
the treated and control groups displayed minimal irritation. Based
on the scores of dermal irritation, test substance MRD-83-206 would not
be considered a dermal sensitizer under the EU GHS guidelines or under
the EU requirements for dangerous substances and preparations guidelines.
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