Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: -
CAS number: -
response data for each animal at each observation time up to removal of
each animal from the test
Score at time point / Reversibility
Max. score: 4
Max. score: 2
Max. score: 3
Average 24h, 48h, 72h
Average time (unit) for reversion
c. = completely reversible; = not completely reversible; n. = not
is being read across from the source study that tested Hydrocarbons,
C14-C17, n-alkanes, <2% aromatics based on analogue read across.
irritant effect of Petrepar-147 was investigated according to the OECD
Guideline No. 405 (1981).
Three albino rabbits were exposed to 0.1 mL
of the test article in one eye. The eyes were examined and the changes
were graded according to a numerical scale 1, 24, 48 and 78 hrs and on
day 4 and 7 after dosing. The eyes were not rinsed after administration
of the test substance.
No corneal damage or iridal inflammation was
observed. Redness and chemosis were observed in all animals, one hour
after instillation. Slight redness was still observed in two animals at
24 hours while slight chemosis was only observed in one rabbit. The eyes
of all rabbits were normal 48 hours after instillation. The mean
individual scores were 0.33/0.33/0.0 for conjunctival redness and
0.33/0.0/0.0 for chemosis.
Petrepar-147 is not considered as irritating
to the eyes according to Annex VI of the Directive 67/548/EEC and CLP
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again