Registration Dossier
Registration Dossier
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EC number: 213-208-3 | CAS number: 930-02-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1987-12-17 to 1988-02-08
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Equivalent or similar to OECD guideline 401. No GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- 1981
- Deviations:
- not specified
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 1-(vinyloxy)octadecane
- EC Number:
- 213-208-3
- EC Name:
- 1-(vinyloxy)octadecane
- Cas Number:
- 930-02-9
- Molecular formula:
- C20H40O
- IUPAC Name:
- 1-(ethenyloxy)octadecane
- Test material form:
- other: colourless liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dr. Thomae GmbH; D-7950 Biberach; Germany
- Weight at study initiation: Males: 189 g; Females: 180 g
- Fasting period before study: about 16 hours
- Housing: Stainless steel wire mesh cages; type DK-III (Becker Co., Castrop-Rauxel, Germany)
- Diet: Kliba Labordiät 343, Klingentalmühle AG, CH-4303 Kaiseraugst, Switzerland, ad libitum
- Water: tap water ad libitum
- Acclimation period: at least 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 24
- Humidity (%): 30 - 70
- Photoperiod (hrs dark / hrs light): 12/12 (6 .00 - 18 .00 hours/18 .00 - 6 .00 hours )
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: olive oil
- Details on oral exposure:
- FASTING PERIOD
- Animals were given no feed about 16 hours before administration, but water was available at libitum
VEHICLE
- Test substance formulation with: olive oil
- Concentration in vehicle: 50 (w/v)
- Amount of vehicle (if gavage): 10 mL/kg
- Justification for choice of vehicle: test substance is insoluble in water
MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- 10 (5 males/5 females) per dose
- Control animals:
- no
- Details on study design:
- - Time of day of observation: in the morning
- Duration of observation period following administration: 18 days
- Frequency of observations and weighing: observation: daily; weighing: day 0, 6 and 13
- Necropsy of survivors performed: yes
- Other examinations performed: gross pathological examination - Statistics:
- NA
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortalities
- Clinical signs:
- other: No clinical signs
- Gross pathology:
- No abnormalities
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information
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