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EC number: 213-208-3
CAS number: 930-02-9
Viability / Mortality: No deaths occurred
during the study period.
Clinical Signs: No symptoms of local
toxicity at the ears of the animals and no systemic findings were
observed during the study period.
Body Weights: The body weight of the
animals, recorded prior to the first application and prior to treatment
with 3HTdR, was within the range commonly recorded for animals of this
strain and age.
Lymph Node Weights and Cell Counts: The
measured lymph node weights and cell counts of all animals treated were
recorded after sacrifice. In the high dose group, a statistically
significant and biologically relevant increase in lymph node weight was
observed in comparison to the vehicle control group (p < 0.05). The
lymph node cell count showed no statistically significant increase in
any test item treated group in comparison to the vehicle control group.
However, the cutoff-value for a positive response regarding the lymph
node cell count index of 1.55 reported for BALB/c mice was exceeded in
this group and was therefore considered to be biologically relevant
(index of 1.6).
Ear Weights: The measured ear weights of all
animals treated were recorded after sacrifice. A statistically
significant increase in ear weights was observed in the low and the high
dose group in comparison to the vehicle control group (p<0.05). However,
the cutoff-value for a positive response regarding the ear weight index
of 1.1 reported for BALB/c mice was not exceeded in any dose group.
Still, the mentioned cutoff-value has been determined using a different
strain of mice and can thus not be implicitly adopted.
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