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EC number: 233-520-3
CAS number: 10213-78-2
measured BCF fish is available for the primary fatty amine ethoxylates.
OECD 305 tests are technically not feasible with these strongly sorbing
easily degradable substances. In addition is the route of exposure in a
standard OECD 305 test unrealistic for these substances because the
substance will either be sorbed or biodegraded. The bioaccumulation
potential of primary fatty amine ethoxylates was therefore assessed
based on a measured log Kow. As indicated before, primary fatty amine
ethoxylates are readily biodegradable and it is therefore unlikely that
they will accumulate in the food chain. Since there is a measured log
Kow value available this value is used to assess the bioaccumulation
valid measured log Kow values are however available as presented in the
Primary fatty amines ethoxylates
Measured log Kow
2,2'-(C12-18 evennumbered alkyl imino) diethanol
2,2'-(C16-18 (evennumbered) alkyl imino) diethanol
highest log Kow is observed for 2,2'-(C16-18 (evennumbered) alkyl imino)
diethanol (CAS no 1218787-30-4). For this product also the lowest CMC of
3.5 mg/L was observed. The measured log Kow value of 3.6 indicates a
moderate bioaccumulation potential for narcotic substances. For polar
narcotics like the primary fatty amine ethoxylates however there is only
limited information on the relationship between log Kow and BCF.
vitrobiotransformation of C12to C18alkyldiethanolamines
was therefore tested according to a slightly adaptedCellzdirect/Invitrogen
Hepatic Rainbow Trout S9 Incubation Protocol using testosterone as
results show thatC12–
C18alkyldiethanol amines are quickly metabolized.
summary of the mean observed biotransformation rates, the predicted
whole body metabolism rate (Kmet) and BioConcentration Factor
(BCF) are presented in the Table below. The Kmetand BCF
values were estimated using a calculation spreadsheet obtained from John
Nichols (USEPA, personal communication). The BCF is calculated assuming
reduction in bioavailability in the test is functionally identical to
the reduction in bioavailability in fish plasma (fu= 1).
Summary of data in relation to the bioaccumulation potential of alkyl
Alkyl chain length
using OECD 123*
Slope of log transformed substrate depletion curve**
Estimated Partitioning based BCF(L/kg)
BCF with biotransformation (L/kg)
-0.119 ± 0.034
-0.103 ± 0.017
-0.051 ± 0.012
-0.011 ± 0.005
2010a, b and c
** Negative values represent
the decrease of the test substance
observed rapid biotransformation of the C12 to C18 alkyldiethanol
amines (RSS under 6.5) demonstrates that it will be very unlikely that
these substances will accumulate in fish. This was confirmed by the
calculated BCF values which where all below the CLP threshold value of
500 L/kg. It is therefore concluded that C12 to C18alkyldiethanolamines
have a low bioaccumulation potential and that anin vivoevaluation
of the bioaccumulation potential by e.g. performing an OECD 305
bioaccumulation test is not expected to result in BCF values > 500 L/kg.
weight evidence of each of the fate points (log Kow, metabolism,
biodegradability, bioavailability, BCF model) separately is limited but
when considered together it is justified to concluded that primary alkyl
amine ethoxylates (2EO) will not accumulate in the food chain and have a
low bioaccumulation potential.
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