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EC number: 233-520-3
CAS number: 10213-78-2
ased on the available studies on biodegradation, the substances are estimated to be readily biodegradable. The 10-days-window criterion should not be evaluated for a UVCB thus there is no requirement for performing a soil biodegradation test (Annex IX. 188.8.131.52). No simulation tests for degradation rates under environmental conditions are available for primary fatty amine ethoxylates but for a very similar substance (hexadecyl amine) and these results will be used for read-across to primary fatty amine ethoxylates (2EO). For soil and aerobic sediment this is a half-life value of 17 days at 12 °C.
In addition a waste water treatment simulation test was performed with 2,2’(octadec-9-enylimino)-bisethanol (25307-17-9). More than 99.999% removal was observed using specific chemical analyses (LCMS/MS) of the effluent during day 44 to 48 (n=5). Also the sorption to sludge was measured and this accounted for 0.16 % of the total removal which means that 99.83% is removed by biodegradation.
Biodegradation in a
sewage treatment simulation test:
More than 99.999%
removal is observed for 2,2’(octadec-9-enylimino)-bisethanol
(25307-17-9) in waste water treatment simulation test. From this removal
99.83% is removed via biodegradation and 0.16 % via sorption. The test
result can be used for the other primary fatty amine ethoxylates as a
worst-case because all primary fatty amine ethoxylates
The removal ofoctadecenyl
biological treatment plants was simulated in a continuously-fed
activated sludge (CAS) unit fed with domestic wastewater spiked with octadecenyl
bis(2-hydroxyethyl)amine was exposed to micro-organisms maintained by
addition of domestic wastewater in the CAS test. Octadecenyl
bis(2-hydroxyethyl)amine was spiked at a nominal influent concentration
of 50 mg/L (37.0 mg/L carbon; calculated) for a period of 48 days and
included a control fed with domestic wastewater only.
immediate high removal percentages can be attributed to adsorption and
probably biodegradation. The mean removal percentage of octadecenyl
bis(2-hydroxyethyl)amine calculated over 15 measurements obtained from
day 34 to 48 of the test was 102±0.8%
(95% confidence interval). These high removal percentages strongly
indicate that octadecenyl bis(2-hydroxyethyl)amine is biodegraded
completely. Formation of water soluble compounds during biological
treatment of octadecenyl bis(2-hydroxyethyl)amine can be excluded. An
accurate assessment of the removal of octadecenyl
bis(2-hydroxyethyl)amine was established with specific analyses. The
mean removal percentage of octadecenyl bis(2-hydroxyethyl)amine in the
test unit was quantified from day 44 to 48 and was more than 99.999%
representative component as a worst-case. These
analyses demonstrate that the removal of octadecenyl
bis(2-hydroxyethyl)amine is complete. Octadecenyl
bis(2-hydroxyethyl)amine concentrations in the mixed liquid suspended
solids (activated sludge) of the reactor sampled on days 47 and 48 were
3.2 mg/L. Mean removal percentages of octadecenyl
bis(2-hydroxyethyl)amine from the influent through adsorption onto
sludge assessed in two samples was therefore 0.16% demonstrating that
octadecenyl bis(2-hydroxyethyl)amine is primarily removed by
In conclusion, the CAS
test demonstrates thatoctadecenyl
completely removed from the wastewater in conventional biological
wastewater treatment plants.Octadecenyl
primarily removed by biodegradation.
derivation of the default half-life’s the bioavailability is taken into
account via the sorption properties of the substance. This is realistic
for soluble non-toxic substances. For poorly soluble/strongly sorbing
substances however, the degradation rate in a standard ready test is
limited by the dissolution rate and in many cases not 60% degradation is
achieved within 28 days but in a slightly longer time frame. Such a
substance is in fact completely degraded to CO2and H2O
and thus completely biodegradable. The bioavailable fraction is readily
biodegradable but the due to the stringency of the test setup the
substance this cannot be observed.
was determined as 4526 L/kg. The suggested maximum half-life for a
readily degradable substance with a Kpsoil in the range >1000 and <
10000 L/kg is 3000 days for soil (at 12 ºC). These values are considered
as extremely conservative but in the absence of measured data can be
used in the exposure assessment as a worst-case. The half-life of the
bioavailable fraction of primary fatty amine ethoxylates in the water
phase of soils is expected to be in the order of a few days, which is
based on experiments with dialkyldimethylammonium salts (van Ginkel et
across from primary alkyl amines
a substance which isvery similar to
2,2'-(C12-18 evennumbered alkyl imino) diethanol (CAS no 71786-60-2)
there is an OECD
307 aerobic soil transformation study available and the results of this
study will be used for read across to the primary alkyl amine
ethoxylates for both the soil and sediment compartment. Although this
C16 amine is strongly sorbing to soil (median Kp soil of 3875 L/kg at
lowest measured concentration) the following half-life’s at 20 °C were
determined for three soils: Soil 1 t1/2 = 9.0 d; Soil 2 t1/2 = 8.1 d;
Soil 3 t1/2 = 8.9 d.
The median Half-life of
8.9 d at 20 °C corresponds to a median Half-life of 16.9 d at an
environmental temperature of 12 °C (see REACH Guidance). This study
demonstrates that 1-Hexadecanamine (C16 amine) is rapidly degraded in
various soils and the results indicate that the assumption of low
degradation rates for strongly sorbing substances could be unjustified.
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