Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 233-520-3
CAS number: 10213-78-2
The study was performed to assess the acute
toxicity of the test material
following a single oral administration to the Sprague-Dawley strain rat. The
study was performed according to OECD guideline 401. Following a
range-finding study, a group of ten fasted animals (five male and five
female) was given a single, oral dose of the test material at a dose
level 2000 mg/kg bodyweight. The animals were observed for 14 days after
the day of dosing and were then killed for gross pathological examination.
One female was found dead 2 days after dosing. Clinical signs of
toxicity noted were hunched posture and pilo-erection 1 and 4 h after dosing.
Most survivors showed expected gains in bodyweight over the study period;
in 2 female rats bw gain was reduced or slight body weight loss was observed.
No abnormalities were noted in survivors at necropsy; the deceased animal
showed abnormally red lungs, dark liver and kidneys and haemorrhage of
the gastric mucosa. The acute median lethal dose (LD50) of the test
material was found to be greater than 2000 mg/kg bodyweight. The test
material was considered not to have significant acute toxicity and does require
classification in Category V, according to OECD-GHS (based on 10% mortality
at 2000 mg/kg bw and 1/2 dead animals at 5000 mg/kg bw).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again