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EC number: 265-084-5
CAS number: 64741-82-8
A complex combination of hydrocarbons from the distillation of the products from a thermal cracking process. It consists predominantly of unsaturated hydrocarbons having carbon numbers predominantly in the range of C10 through C22 and boiling in the range of approximately 160°C to 370°C (320°F to 698°F).
Table 1. Body weight
Gestational day 0
226.3± 9.9 **
Gestational day 20
Lactational day 0
Lactational day 4
different from the control * p<0.05; ** p<0.01
Table 2. Food consumption (g/kg/day)
Day -7 to -1
Gestational day 0 to 4
Gestational day 16 to 20
Lactational day 0 to 4
Table 3. Pup body weight data
Groups of female Sprague-Dawley rats
received 0 (sham control), 1, 50 or 250 mg/kg body weight/day of light
coker gas oil dermally. Treatment of the females commenced one week
prior to mating with untreated males. Pregnant females were then
assigned to the test (n = 12/dose level) and control groups (n = 15) and
treatment continued until gestation day (GD) 20. The test material was
applied to clipped dorsal skin (area unspecified) and the animals fitted
with Elizabethan collars for 6 hours post-treatment to prevent
ingestion, after which time the test site was wiped clean. It was not
stated if the application site was covered or left open.
The dams were observed at intervals
during gestation and up to lactation day (LD) 4 for viability, general
health and toxicity, dermal irritation, body weight and food consumption
followed by necropsy and a gross external and internal examination
(which included the uterus and its contents). Pup parameters assessed at
the time of delivery and on LD 4 included sex, body weight, presence of
gross abnormalities and survival.
None of the dams died during the
course of the study. Slight to moderate erythema, oedema and eschar were
present at the treatment site in the low- and mid dose groups (present
during days 5-6 of the premating period), with more severe responses
(including slight to severe erythema, ulceration in one animal) recorded
in the 250 mg/kg body weight/day group. Mean body weight for the period
GD 0-20 was decreased by approx. 10% (significant) in high dose animals,
with a comparable (significant) reduction in weight gain on GD 0-4.
Maternal body weight at LD 4, and weight gain during the period LD 0-4,
were also significantly decreased in postnatal dams from the 250 mg/kg
body weight/day group.
With the exception of a significantly
decreased mean pup weight at birth (-7%) and at LD 4 (-14%) for the high
dose litters, no toxicologically relevant effects were reported for the
Based on these results, the authors of
the study determined a NOAEL of 50 mg/kg body weight/day for effects of
light coker gas oil
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